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  • Research home > Beat Cancer Project search > Optimising Cancer Therapy through Development of Evidence-Based Dose Individualisation Strategies

    Optimising Cancer Therapy through Development of Evidence-Based Dose Individualisation Strategies

    Dr Stephanie Reuter Lange
    • Donor Funding: $300,000
    • Cancer Type: All Cancers
    • Cancer Stage: Treatment
    • Funded in: 2020
    • Dr Stephanie Reuter Lange
      University of South Australia

    Whilst there has been substantial improvements in the treatment of cancer, it remains that 3 out of 10 patients will not survive longer than 5 years, a result of either cancer progression or death from severe treatment-related side effects. Cancer medicines must be administered at a dose that is enough to treat the cancer, but not too much to cause toxic side effects. While this is well known, most cancer treatments are given as a “one-size-fits-all” amount. Given the large variability in response seen with many cancer medicines, this means that for the same dose some patients are likely to be under-treated and others a likely to be over-treated. The concept of dose individualisation is tailoring the amount of drug administered to each individual patient to maximise tumour response and minimise side effects. This fellowship program will use computer-based modelling methods to identify dose individualisation strategies for best treatment practice. This will be conducted for a range of diverse projects that will illustrate the value in this approach to cancer treatment and provide a framework for determining the best use of new and existing cancer medicines.



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