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  • Research home > Beat Cancer Project > FANC gene mutations in Acute Myeloid Leukaemia biology and treatment

    FANC gene mutations in Acute Myeloid Leukaemia biology and treatment

    Professor Richard D'Andrea
    • Donor Funding: $75,000
    • Cancer Type: Blood cancers
    • Cancer Stage: Treatment
    • Funded in: 2018
    • Professor Richard D'Andrea
      University of South Australia

    The role of FANC gene variants in AML. We have found mutations in DNA repair genes in AML patients, and associated the presence of these with increased risk of developing AML. Our hypothesis is that the presence of these mutations leads to reduced efficiency of DNA repair, and increased risk of additional mutations and leukaemic transformation. Our aim is therefore to determine the changes associated with these mutations in blood cell precursors, and to investigate the potential of targeted therapies for this group of patients.



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