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Trial Summary

The primary purpose of this trial is to compare the effect of simvastatin with placebo on the effectiveness and side effects of pre-operative chemoradiotherapy treatment prior to rectal cancer surgery, and on the body’s inflammatory response to cancer.

Acronym:

SPAR

ACTRN/NCT /ethics:

ACTRN12617001087347

Scientific title:

A clinical trial comparing Simvastatin to placebo, in addition to standard chemotherapy and radiotherapy, in preoperative treatment for patients with rectal cancer. | SPAR

Sponsor / Cooperative group:

AGITG

Trial & Patient Characteristics

Cancer TypeBowel and colon
Trial TypeTreatment
PhasePhase II
Age Range18 years and older
SexBoth
Tumour Stream Rectal cancer
Cancer StageAll stages
Anticipated Start Date2017-10-02
Anticipated End Date2020-10-02

Participating Hospitals

HospitalThe Queen Elizabeth Hospital
Clinical Trial CoordinatorPamela Cooper
Emailpamela.cooper@sa.gov.au
Phone08 8222 6140
Principal InvestigatorProfessor Tim Price
Recruitment StatusRecruiting
HospitalFlinders Medical Centre
Clinical Trial CoordinatorAlex Scott-Hoy
Emailalex.scott-hoy@sa.gov.au
Phone08 8204 4830
Principal InvestigatorDr Chris Karapetis
Recruitment StatusNot Yet Recruiting