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  • ASLAN Billary

    Acronym: 

    TreeTopp

    ACTRN/NCT /ethics: 

    NCT03093870

    Scientific title: 

    Varlitinib in Combination With Capecitabine for Advanced or Metastatic Biliary Tract Cancer (TreeTopp)

    Summary of trial and patient characteristics

    Cancer Type Gall Bladder
    Trial Type Treatment
    Phase Phase III, Phase II Tumour Stream Biliary tract cancer
    Age Range All ages Cancer Stage Metastatic or Widespread, Locally Recurrent or Locally Advanced
    Sex Both Anticipated Start Date 2017-07-04
    Molecular Target Anticipated End Date 2019-07-01
    Cancer Type Gall Bladder
    Trial Type Treatment
    Phase Phase III, Phase II
    Age Range All ages
    Sex Both
    Molecular Target
    Tumour Stream Biliary tract cancer
    Cancer Stage Metastatic or Widespread, Locally Recurrent or Locally Advanced
    Anticipated Start Date 2017-07-04
    Anticipated End Date 2019-07-01

    Trial Summary

    This protocol for Varlitinib is developed for the treatment of Biliary Tract Cancer. Varlitinib (also known as ASLAN001) is a small-molecule, adenosine triphosphate competitive inhibitor of the tyrosine kinases - epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER)2, and HER4. Varlitinib may be beneficial to subjects with cancer by simultaneous inhibition of these receptors. The purpose of this study is to determine the safety and efficacy of Varlitinib in combination with capecitabine for the treatment of Biliary Tract Cancer. Treatment groups are Varlitinib+capecitabine and Placebo + capecitabine

    Lay Summary

    Varlitinib in Combination With Capecitabine for Advanced or Metastatic Biliary Tract Cancer (TreeTopp)

    Sponsor / Cooperative group

    Aslan Pharmaceuticals

    Participating Hospitals

    Hospital Clinical Trial Coordinator Email Phone Principal Investigator Recruitment Status
    Flinders Medical Centre Alex Scott-Hoy alex.scott-hoy@sa.gov.au 08 8204 4830 Chris Karapetis Recruiting