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  • ELIMINATE

    Acronym: 

    ELIMINATE

    ACTRN/NCT /ethics: 

    ACTRN12614000515695

    Scientific title: 

    Women with ER-positive, HER2-negative, grade 2/3 invasive breast cancer 20 mm in a Phase II study randomized to receive standard neoadjuvant chemotherapy concurrently with an aromatase inhibitor compared with standard neoadjuvant chemotherapy only to compare the rate of downstaging to pathological stage 0 or 1A.

    Summary of trial and patient characteristics

    Cancer Type All cancers, Breast
    Trial Type Treatment
    Phase Phase II Tumour Stream Breast
    Age Range 18 years and older Cancer Stage All stages
    Sex Female Anticipated Start Date 2015-05-25
    Molecular Target Anticipated End Date 2015-06-01
    Cancer Type All cancers, Breast
    Trial Type Treatment
    Phase Phase II
    Age Range 18 years and older
    Sex Female
    Molecular Target
    Tumour Stream Breast
    Cancer Stage All stages
    Anticipated Start Date 2015-05-25
    Anticipated End Date 2015-06-01

    Trial Summary

    This study aims to add hormone treatment (aromatase inhibitor (letrozole)) to standard neoadjuvant chemotherapy and find out if this treatment is more effective in reducing the size of large breast cancers before surgery. More effective down-staging of large breast cancers before surgery increases the likelihood of achieving a complete surgical resection and can increase the rate of breast conserving surgery.

    Lay Summary

    Women with ER-positive, HER2-negative, grade 2/3 invasive breast cancer 20 mm in a Phase II study randomized to receive standard neoadjuvant chemotherapy concurrently with an aromatase inhibitor compared with standard neoadjuvant chemotherapy only to compare the rate of downstaging to pathological stage 0 or 1A.

    Sponsor / Cooperative group

    Australian and New Zealand Breast Cancer Trials Group

    Participating Hospitals

    Hospital Clinical Trial Coordinator Email Phone Principal Investigator Recruitment Status
    Flinders Medical Centre Alex Scott-Hoy alex.scott-hoy@sa.gov.au 08 8204 4830 Bogda Koczwara Recruitment on Hold
    The Royal Adelaide Hospital Anne Milton anne.milton@sa.gov.au 08 70742342 Recruiting