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  • VIPER

    Acronym: 

    Viper

    ACTRN/NCT /ethics: 

    ACTRN12616001021460

    Scientific title: 

    Sodium Valporate/ Metformin combination therapy for prostate cancer (VIPER 1 trial)

    Summary of trial and patient characteristics

    Cancer Type Prostate
    Trial Type Treatment
    Phase All phases Tumour Stream Prostate
    Age Range 18 years and older Cancer Stage All stages
    Sex Male Anticipated Start Date 2016-12-01
    Molecular Target Anticipated End Date
    Cancer Type Prostate
    Trial Type Treatment
    Phase All phases
    Age Range 18 years and older
    Sex Male
    Molecular Target
    Tumour Stream Prostate
    Cancer Stage All stages
    Anticipated Start Date 2016-12-01
    Anticipated End Date

    Trial Summary

    The primary purpose of this trial is to evaluate the safety and tolerability of Metformin (MET) in combination with sodium valproate (VPA) for the treatment of prostate cancer. Who is it for? You may be eligible to participate in this trial if you are aged 18 or over and have been diagnosed with localised or locally advanced prostate cancer for which radical prostatectomy is planned within the next 6-8 weeks. Study details Participants enrolled in this trial will receive a combination of MET and VPA in increasing doses depending on the cohort they are enrolled in. The study drugs will be administered for a total of 4 weeks just prior to the planned surgery for removing the prostate It is hoped that this trial will provide information on the optimal dose of MET plus VPA to administer to prostate cancer patients, which may be an effective treatment which is safe and tolerated by patients.

    Lay Summary

    Sodium Valporate/ Metformin combination therapy for prostate cancer (VIPER 1 trial)

    Sponsor / Cooperative group

    Participating Hospitals

    Hospital Clinical Trial Coordinator Email Phone Principal Investigator Recruitment Status
    Flinders Medical Centre Alex Scott-Hoy alex.scott-hoy@sa.gov.au 08 8204 4830 Ganessan Kichenadasse Recruiting