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Trial Summary

This is a randomised, phase III, non-inferiority trial evaluating radiation therapy versus observation following breast conserving surgery and planned endocrine therapy in patients with stage I breast cancer of luminal A subtype defined using the Prosigna (PAM50) Assay.



ACTRN/NCT /ethics:


Scientific title:

A Randomised Phase III Trial of Adjuvant Radiation Therapy Versus Observation Following Breast Conserving Surgery and Endocrine Therapy in Patients With Molecularly Characterised Luminal A Early Breast Cancer

Sponsor / Cooperative group:

Breast Cancer Trials, Australia and New Zealand

Trial & Patient Characteristics

Cancer TypeBreast
Trial TypeTreatment
PhasePhase III
Age Range50 Years and older
Tumour Stream -
Cancer StageLocally Recurrent or Locally Advanced
Anticipated Start Date2021-08-21
Anticipated End Date2023-12-01

Participating Hospitals

Clinical Trial CoordinatorKimberley Ruxton
Principal InvestigatorDr Phuong Tran
Recruitment StatusRecruiting