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Treatment for skin cancer

Skin cancer is treated in different ways. Treatment depends on:

  • the type, size and location of the cancer
  • your general health
  • any medicines you are taking (these can affect the amount of bleeding and the healing time)
  • whether the cancer has spread to other parts of your body.

If the biopsy has removed all the cancer, you may not need any further treatment.

Many of the treatments below are suitable for sunspots as well as skin cancers. Some sunspots may need treatment if they are causing symptoms or to prevent them becoming cancers.

Surgery is the most common treatment for skin cancer. The type of procedure you have will depend on the size and position of the cancer.

Most small skin cancers are removed by a GP or a dermatologist. A surgeon may treat more complex cases.

The doctor will inject a local anaesthetic to numb the affected area, then cut out the skin cancer and some nearby normal-looking tissue (margin). A pathologist checks the margin for cancer cells to make sure the cancer has been completely removed. The results will be available in about a week. If cancer cells are found at the margin, you may need further surgery or radiation therapy.

Mohs surgery

Mohs surgery, or microscopically controlled excision, is usually done under local anaesthetic by a dermatologist.

It is used to treat skin cancers that have begun to spread deep into the skin or come back (recurred). It can also be used for cancers in areas that are hard to treat, such as near the eye or on the nose, lips and ears.

This procedure is done in stages. The doctor removes the cancer little by little and checks each section of tissue under a microscope. They keep removing tissue until they see only healthy tissue under the microscope, and then close the wound with stitches or, sometimes, a skin flap or graft. Mohs surgery reduces the amount of healthy skin that is removed while making sure all the cancer is taken out. Mohs surgery costs more than other types of surgery.

Special equipment is needed so it’s available only at some hospitals or clinics.

Repairing the wound

If you have a large skin cancer removed, the wound is covered with a skin flap or skin graft.

For a skin flap, nearby loose skin or fatty tissue is moved over the wound and stitched. For a skin graft, a thin piece of skin is removed from another part of the body and stitched over the wound. These procedures may be performed in the doctor’s office but are sometimes done as day surgery in hospital under a local or general anaesthetic.

Download our booklet ‘Understanding Surgery’

Curettage and electrodessication (or cautery) is used to treat some BCCs and squamous cell carcinoma in situ (Bowen’s disease). It is usually done by a dermatologist.

The doctor will give you a local anaesthetic and then scoop out the cancer using a small, sharp, spoon-shaped instrument called a curette. Low-level heat (electrodessication or cautery) will be applied to stop the bleeding and destroy any remaining cancer. The wound should heal within a few weeks, leaving a small, flat, round, white scar.

Cryotherapy, or cryosurgery, is a procedure that uses extreme cold (liquid nitrogen) to remove sunspots and some small BCCs.

The doctor, usually a dermatologist, sprays liquid nitrogen onto the sunspot or skin cancer and a small area of skin around it. You may feel a burning or stinging sensation, which lasts a few minutes. The liquid nitrogen freezes and kills the abnormal skin cells and creates a wound. In some cases, the procedure may need to be repeated.

The treated area will be sore and red. A blister may form within a day. A few days later, a crust will form on the wound. The dead tissue will fall off after 1–4 weeks, depending on the area treated.

New, healthy skin cells will grow and a scar may develop. The area will heal in a few weeks, and the healed skin will probably look paler than the surrounding skin.

Some skin spots and cancers can be treated with creams or gels that you apply to the skin. These are called topical treatments. They may contain immunotherapy or chemotherapy drugs, and are prescribed by a doctor. You should use these treatments only on the specific spots or areas that your doctor has asked you to treat. Don’t use leftover cream to treat new spots that have not been assessed by your doctor.

Immunotherapy cream

A cream called imiquimod is a type of immunotherapy that causes the body’s immune system to destroy cancer cells.

It is used to treat sunspots, superficial BCCs and squamous cell carcinoma in situ (Bowen’s disease). You apply imiquimod directly to the affected area every night, usually five days a week for six weeks. Within days of starting imiquimod, the treated skin may become red, sore and tender to touch. The skin may peel and scab over before it gets better. Some people have pain or itching in the affected area, fever, achy joints, headache and a rash. If you experience any of these more serious side effects, stop using the cream and see your doctor immediately.

Chemotherapy cream

5-fluorouracil (5-FU) – This cream is a type of chemotherapy drug. It is used to treat superficial BCCs, sunspots and, sometimes, squamous cell carcinoma in situ (Bowen’s disease).

5-FU works best on the face and scalp. Your GP or dermatologist will explain how to apply the cream and how often. Many people use it twice a day for 2–3 weeks. It may need to be used for longer for some skin cancers. While using the cream, you will be more sensitive to UV radiation and will need to stay out of the sun. The treated skin may become red, blister, peel and crack, and feel uncomfortable. These effects will usually settle within a few weeks of treatment finishing.

Ingenol mebutate – This gel is applied to the affected sunspots once a day for two to three days. Side effects can include skin reddening, flaking or scaling, mild swelling, crusting or scabbing, and blisters. These side effects should disappear within a couple of weeks of treatment finishing.

Photodynamic therapy (PDT) uses a cream and a light source to make the cancer sensitive to light. It is used to treat sunspots, superficial BCCs and squamous cell carcinoma in situ (Bowen’s disease).

First the GP or dermatologist gently scrapes the area with a curette to remove any dry skin or crusting. Then the light-sensitive cream is applied, and after three hours a special light is shined onto the area for about eight minutes. The area is covered with a bandage. For skin cancers, PDT is usually repeated after a week.

Side effects can include redness and swelling, which usually ease after a few days. PDT commonly causes a burning, stinging or tender feeling in the treatment area, particularly to the face. Your doctor may treat you with a cold water spray or pack, or give you a local anaesthetic to help ease any discomfort.

Radiation therapy (also called radiotherapy) uses radiation such as x-rays or electron beams to damage or kill cancer cells. It is used for BCC or SCC in areas that are difficult to treat with surgery, such as the face. Sometimes it is also used after surgery to prevent the cancer from coming back or spreading.

You will lie on a table while the radiation therapy machine is positioned around you. This can take 10–30 minutes, but the treatment itself will take only a few minutes. The number of treatments you have depends on the type of skin cancer, where it is and how big it is. Radiation therapy is usually given five times a week for several weeks.

Skin in the treatment area may become red and sore 2–3 weeks after treatment starts. This redness and soreness may last for a few weeks after treatment has finished.

Download our booklet ‘Understanding Radiation Therapy’

If the cancer has spread, the doctor may recommend removing the lymph nodes in an operation called a lymph node dissection. This helps reduce the chance of the cancer spreading to other parts of the body or coming back. For more information, speak to your doctor.

Featured resources

Basal and Squamous Cell Carcinoma - Your guide to best cancer care

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Understanding Skin Cancer

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This information is reviewed by

This information was last reviewed in January 2020 by the following expert content reviewers: Prof Diona Damian, Dermatologist, The University of Sydney at Royal Prince Alfred Hospital, and Associate, Melanoma Institute of Australia, NSW; Dr Annie Ho, Radiation Oncologist, Genesis Care, Macquarie University, St Vincent’s and Mater Hospitals, NSW; Rebecca Johnson, Clinical Nurse Consultant, Melanoma Institute of Australia, NSW; Shannon Jones, SunSmart Health Professionals Coordinator, Cancer Council Victoria; Liz King, Skin Cancer Prevention Manager, Cancer Council NSW; Roslyn McCulloch, Consumer; Caitriona Nienaber, 13 11 20 Consultant, Cancer Council WA; Paige Preston, Policy Advisor, Cancer Prevention, Health and Wellbeing, Cancer Council Queensland; Dr Michael Wagels, Plastic and Reconstructive Surgeon, Princess Alexandra Hospital, QLD. Thanks also to Sydney Melanoma Diagnostic Centre for providing the dysplastic naevus photograph, and to Prof H Peter Soyer for providing the other photographs. We also thank the health professionals, consumers and editorial teams who have worked on previous editions of this title.